S.E.M.I.: Side Effects May Include...

    Up to four players cooperate as patients to escape a clinic, facing staff and unpredictable events.

    Two Horn Unicorn

    Playing together

    Online co-op
    1 source
    Players in online co-op
    1 source
    Early access
    1 source
    Not known yet
    Online versus, Online multiplayer, Players online, Best with, How co-op works, Crossplay, Local co-op, Multiplayer through mods, One copy is enough, Free to play, Plays in browser, Demo, Playtest

    Hover, focus or tap a fact to see where it came from.

    How you talk

    Not known yet
    Plays without voice or typing, Wordless tools, Public matchmaking, Friendly with strangers

    About the game

    S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.
    From IGDB

    Screenshots

    Why we rate it this way

    • 86% positive from 113 Steam reviews.
    Steam, checked 1 Nov 2026Num reviews: 1Review score: 8Review score desc: Very PositiveTotal positive: 97Total negative: 16Total reviews: 113{"num_reviews":1,"review_score":8,"review_score_desc":"Very Positive","total_positive":97,"total_negative":16,"total_reviews":113}

    Sources

    First listed 1 Nov 2026. Updated 1 Nov 2026.